PROFESSOR ENG OOISpecialist Ear Nose and Throat Surgeon
Qualifications: FRACS, PhD, M.B.B.S
Australian and New Zealand Rhinologic Society
Fellow of the Royal Australasian college of surgeons
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Research publications by Professor Eng Ooi

Professor Ooi is an academic ENT surgeon scientist who believes in providing the best care for his patients based on the latest research evidence, and personal clinical experience. He runs several major research projects and clinical trials through his private practice, Flinders Medical Centre, and Flinders University. His PhD in research and role as Head of ENT at Flinders Medical Centre strengthens the care he offers patients in his private practice.

He has research interests in chronic sinusitis, advanced endoscopic sinus surgery,  skull base surgery, biomarkers for tonsil, head and neck cancer, NHMRC trial of UPPP and Coblation tongue channeling for OSA, nerve stimulation and medications for treating sleep apnoea, use of lasers and surgical simulation to improve training.

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Research publications:

  1. The evolution of pituitary surgery in an Australian Healthcare Framework. Accepted in Journal of Neurological Surgery Part B – Skull Base (23.3.24)
  2. Pneumonia and unilateral vocal fold immobility: a single centre six-year review. Timothy J Lee, Theo Athanasiadis, Eng H Ooi. (accepted Feb 28, 2024) AJO 2024; 7:14
  3. The mechanisms of action of metformin on head and neck cancer in the pre-clinical setting: a scoping review. Lucy Huang, Charmaine M Woods, Nuwan Dharmawardana, Michael Michael, Eng H Ooi Frontiers in Oncology 14: 1358854 doi: 10.3389/fonc.2024.1358854
  4. Double blind randomized controlled trial measuring the efficacy of nebulized steroid at half dose in comparison to high volume squeeze bottle steroid irrigation in management of patients with chronic rhinosinusitis. International Forum of Allergy & Rhinology (accepted January 30th, 2024)
  5. The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: a multi-center investigation. Hasmat, Shaheen; Heller, Gillian; Cook, Lachlan; et al (accepted by Head and Neck 04/08/23).;
  6. Sleep Apnea Multi-Level Surgery (SAMS) trial: Long-term observational outcomes Pinczel, Alison; Woods, Charmaine; Catcheside, Peter, et al. Accepted by SLEEP 6th August 2023.
  7. Hospital-Avoidance with Outpatient Management of Epistaxis (HOME): Which epistaxis patients packed with a Rapid Rhino are potentially appropriate for outpatient management? Lauren Footner, Charmaine Woods, Lucy Huang, Eng H. Ooi. Australian Journal of Otolaryngology 2023; 6:15
  8. BiZact tonsillectomy: Predictive Factors for post-tonsillectomy haemorrhage from a 1717 case series. Boyuan Mao, Charmaine M. Woods, Theodore Athanasiadis, Patricia MacFarlane, Samuel Boase, Himani Joshi, John Wood, Eng H. Ooi. Clinical Otolaryngology 2023; 48: 672-679.
  9. Clinical application of pharyngeal high-resolution manometry in ENT practice. Sanith Cheriyan, Mistyka Schar, Charmaine Woods, Michal Szczesniak, Charles Cock, Taher Omari, Theodore Athanasiadis, Eng H Ooi. Australian Journal of Otolaryngology 2023. doi: 10.21037/ajo-22-37
  10. Hedges J, Sethi S, Garvey G, Whop L, Canfell K, Dodd Z, Larkins P, Antonsson A, Smith M, Mittinty M, Leane C, Reid N, Ooi E, Ju X, Logan R, Jamieson L The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study JMIR Res Protoc 2023;12:e44593 URL: DOI: 10.2196/44593
  11. Managing Chronic Otitis media with effusion in children with non-syndromic cleft palate: short term ventilation tubes versus surveillance. Grace Maina; Danielle Pollock, Craig Lockwood, Lachlan Cook, Eng Ooi in Cleft Palate Craniofacial Journal (online first on 4 January 2023)
  12. Swallowing biomechanics in tracheostomized critically ill patients compared to age and gender matched healthy controls. Sanith S Cheriyan , Mistyka S Schar , Charmaine M Woods , Shailesh Bihari, Charles Cock, Theodore Athanasiadis, Taher I Omari, Eng H Ooi. Critical Care and Resuscitation 25 (2023): 97-105.
  13. An observational pragmatic quality of life study on paediatric tonsillectomy and waiting for surgery. Julie Huynh, Charmaine Woods, Eng H. Ooi. Accepted by European Archives of Oto-Rhino-Laryngology (12/09/22). 2023 Feb; 280(2): 885-890. doi: 10.1007/s00405-022-07659-2.Epub 2022 Sep 22
  14. Prognostic value of 18-FDG PET volumetric parameters in HPV-related oropharyngeal squamous cell carcinoma. (accepted by Laryngoscope 9/8/22) Anthony Noor, Manish Mair, Lachlan Cook, Harrison Bolt, Sanith Cheriyan, Charmaine Woods, James Hopkins, Eng H. Ooi
  15. A systematic review and meta-analysis of the role of doxycycline in chronic rhinosinusitis. David S Chan, Obaidullah Hisham Khalid, Eng H Ooi. The Journal of Larynology and Otology (accepted 26/7/22)
  16. Anterior pedicled nasal flap in frontal sinus drill-out patients: A randomised controlled pilot study. Mark Bastianelli, Lucy Huang, Paige Moore, Isma Iqbal, Charmaine M Woods, Eng H. Ooi. J Clin Med 2022, 11, 4329
  17. Variation in management of post-tonsillectomy haemorrhage: a survey of Australian Society of Otolaryngology Head and Neck Surgery Consultants and Registrars. Timothy J Lee, John Wood, Eng H. Ooi, AJO 2022; 5:21
  18. Pharyngeal Tongue Base Augmentation for Dysphagia (PAD) therapy: A prospective case series in patients post head and neck cancer treatment. Mistyka Schar, Taher Omari, Charmaine M Woods, Lauren Footner, Nicholas Marshall, Charles Cock, Alison Thompson, Thi Nguyen, Theodore Athanasiadis, Eng Hooi Ooi. Head and Neck 2022, 44(8): 1871-1884.
  19. A retrospective review of spontaneous epistaxis outcomes for patients on novel oral anticoagulants compared to antiplatelets and warfarin. Grace Maina, Eng H. Ooi. Accepted by American Journal of Otolaryngology – Head and Neck Medicine and Surgery 43 (4): (2 May 2022).
  20. Bedside voice assessments cannot be used as a screening test for laryngeal injury following prolonged intubation in an intensive care population. Lucy Huang, Theo Athanasiadis, Mistyka Schar, Charmaine Woods, Ahmed Bassiouni, Stephanie Martin, Jane Bickford, Shailesh Bihari, Eng H Ooi. Aust J Otolaryngol 2022; 5:9
  21. Effectiveness of ventilation tube insertion for conductive hearing loss on children with chronic otitis media with effusion and non-syndromic cleft palate: A systematic review protocol. Grace Maina, Danielle Pollock, Craig Lockwood, Eng Ooi. JBI Evidence Synthesis: February 25, 2022 – Volume – Issue – doi: 10.11124/JBIES-21-00217
  22. Delays in time to head and neck cancer treatment: A South Australian perspective. Lachlan Cook, Charmaine Woods, Tracey Nicholls, Eng H. Ooi. Accepted by Medicina 2022, 58, 145,
  23. Ear microbiota and middle ear disease: a longitudinal pilot study of Aboriginal children in a remote South Australian setting. Steven L. Taylor, Lito E. Papanicolas, Alyson Richards, Furdosa Ababor, Wan Xian Kang, Jocelyn M. Choo, Charmaine Woods, Steve L Wesselingh, Eng H. Ooi, Patricia MacFarlane, Geraint B. Rogers. Accepted by BMC Microbiol Jan 13; 22(1): 24. Doi 10.1186/s12866-022-02436-x
  24. Risk of airway fire with the use of of KTP laser and high flow humidified oxygen delivery in a laryngeal surgery model. Lucy Huang, Adam Badenoch, Marthinus Vermeulen, Shahid Ullah, Charmaine Woods, Theodore Athanasiadis, Eng Hooi Ooi. Scientific reports (accepted 21/12/21). Sci Rep 2022 Jan 11; 12(1): 543. Doi: 10.1038/s41598-021-04636-3
  25. Lee, Timothy J.; Krishnan, Giri; Ooi, Eng H.; Barker, Timothy H. Effectiveness of reduced- versus standard-dose radiotherapy on survival and radiation-associated toxicity in patients with human papillomavirus associated oropharyngeal squamous cell carcinoma, JBI Evidence Synthesis: October 25, 2021 – Volume – Issue – doi: 10.11124/JBIES-21-00159
  26. Swallowing Biomechanics Pre- and Post-Multi-Level Upper Airway Surgery for Obstructive Sleep Apnea. Journal of Clinical Sleep Medicine. 2021 Mistyka Schar, Taher I Omari, Charmaine M Woods, Charles Cock, Sebastian Doeltgen, Ching Li Chai-Coetzer, Danny J Eckert, Athanasiadis T, Ooi, EH. (accepted 24/11/21)
  27. COVIDSurg Collaborative. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. Lancet Oncol. 2021 Oct 5:S1470-2045(21)00493-9. doi: 10.1016/S1470-2045(21)00493-9. Epub ahead of print. PMID: 34624250; PMCID: PMC8492020.
  28. Volumetric MRI analysis of Multilevel Upper Airway Surgery effects on pharyngeal structure. . Accepted by Sleep Jul 20:zsab183. doi: 10.1093/sleep/zsab183. Epub ahead of print. PMID: 34283220.
  29. Trans-oral robotic surgery for head and neck cancers using the Medrobotics Flex® system: the Adelaide cohort. J Robot Surg. 2021 Jul 7. doi: 10.1007/s11701-021-01270-z. Epub ahead of print. PMID: 34232448.
  30. Health related quality of life T-14 outcomes for pediatric BiZact tonsillectomy. Stepan L, Huang L, Huynh J, Xie P, Woods CM, Ooi EH Medicina 2021, 57, 480.
  31. Altered swallow biomechanics in people with moderate-severe obstructive sleep apnoea. Schar MS, Omari T, Woods CW, Ferris L, Doeltgen S, Lushington K, Kontos A, Athanasiadis T, Cock C, Chai-Coetzer CL, Eckert D, Ooi, EH. Journal of clinical sleep medicine (accepted for publication 18/03/21).
  32. Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness among patients with moderate or severe obstructive sleep apnea: The SAMS randomized clinical trial.  JAMA 4/9/20
  33. Breath methane to hydrogen ratio as a surrogate marker of intestinal dysbiosis in head and neck cancer. Nuwan Dharmawardana, Thomas Goddard, Eng H. Ooi, C.M. Woods, David Watson, Ross Butler, and Roger Yazbek. Scientific Reports 10, 15010 (2020) 1038/s41598-020-72115-2
  34. The development of a mon-invasive exhaled breath test for the diagnosis of head and neck cancer. N. Dharmawardana, T. Goddard, C.M. Woods, D. Watson, E.H. Ooi, R. Yazbek. British Journal of Cancer 9/9/20 page 1-7 DOI: 1038/s41416-020-01051-9
  35. Psychometric testing of the Skull Base Inventory Quality of life Questionnaire in a Multi-Institutional Prospective Cohort Study of Patients Undergoing Open and Endoscopic Skull Base Surgery. David Forner MD, Katrina Hueniken BSc MPH, Tom Yoannidis, Ian Witterick, Eric Monteiro, Gelareh Zadeh, Patrick Gullane, Carl Snyderman, Eric Wang, Paul Gardner, Benita Valappil, Dan Fliss, Barak Ringel, Ziv Gil, Shorook Na’ara, Eng H. Ooi, David Goldstein, Nidal Muhanna, Fred Gentili, John R. de Almeida. Quality of Life Research (published 26/08/2020)
  36. Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma. Mayne GC, Woods CM, Dharmawardana N, Wang T, Krishnan S, Hodge JC, Foreman A, Boase S, Carney AS, Sigston EAW, Watson DI, Ooi EH*, Hussey DJ* (* = co-senior
    authors) Journal of Translational Medicine 2020 July 10, 18(1): 280
  37. Is there a role for up to date imaging in patients awaiting sinus surgery?  Australian Journal of Otolaryngology 2020; 3:7
  38. Factors associated with paediatric revision adenoidectomy: The Flinders experience.  Australian Journal of Otolaryngology 2020; 3:9
  39. A review of breath analysis techniques in Head and Neck Cancer. Oral Oncology March 19; 104: 104654
  40. National Surgical Quality Improvement Program (NSQIP) risk calculator validity in South Australian laryngectomy patients. Stephen Shih-Teng Kao, Claire Frauenfelder, Daniel Wong, Suzanne Edwards, Suren Krishnan, Ooi EH. ANZ Journal of Surgery 2020 May; 90(5): 740-745 doi: 10.1111/ans.15807. Epub 2020 Mar 11
  41. Accuracy of core needle biopsy compared to fine needle biopsy for the diagnosis of neoplasm in patients with suspected head and neck cancers: a systematic review protocol of diagnostic test accuracy.  JBI Database System Rev Implement Rep 2020 Jan 8 doi: 10.11124/JBISRIR-D-19-00225 [Epub ahead of print]
  42. Prognosis of oral scc with perineural invasion: A comparative study of classification types. Clinical Otolaryngology 2020 45(1): 99-105
  43. A review of the use of transnasal humidified rapid insufflation ventilatory exchange for patients undergoing surgery in the shared airway setting. Journal of Anesthesia 2020 Feb 34(1): 134-143
  44. Role of biologics in Chronic Rhinosinusitis: A systematic review.  International Forum of Allergy and Rhinology 2020 Feb 10(2): 165-174
  45. Examining the evidence for an adult healthy middle ear microbiome. mSphere Sept 4; 4(5): pii e00456-19 
  46. Manuka Honey sinus irrigations in recalcitrant chronic rhinosinusitis: Phase 1 Randomised double blinded placebo controlled trial.  International Forum of Allergy and Rhinology 2019 Dec; 9(12): 1470-1477
  47. Effectiveness of endoscopic versus external surgical approaches in the treatment of orbital complications of rhinosinusitis: a systematic review protocol. JBI Database System Rev Implement Rep 2019 17(11): 2378-2389.
  48. The use of Selected Ion Flow Tube-Mass Spectrometry technology to identify breath volatile organic compounds for the detection of head and neck squamous cell carcinoma: A pilot study. Medicina 2019, 55, 306
  49. Halitosis and pain post electrocautery adenoidectomy. 55(6): 312; Medicina 2019
  50. The use of transnasal humidified rapid-insufflation ventilatory exchange in laryngeal and pharyngeal surgery: The Flinders case series.  Australian Journal of Otolaryngology 2019; 2:17
  51. Circulating microRNAs in Head and Neck Cancer: A scoping review of methods. Clinical and Experimental Metastasis Jun; 36(3): 291-302
  52. Transoral robotic surgery using the MedRobotic Flex system: the Adelaide experience.  J Robotic Surgery 2020: Feb; 14(1): 109-113
  53. Outcomes using the T-14 symptom score for tonsillectomy in an Australian Paediatric population. Australian Journal of Otolaryngology 2019; 2:2
  54. Tonsillectomy using the BiZact: A pilot study in 186 children and adults  Associate Professor Eng Ooi and Associate Professor Suren Krishnan 44 (3): 392:396, May 2019
  55. Management of post tonsillectomy secondary haemorrhage: Flinders experience.  Australian Journal of Otolaryngology 2018; 1: 31
  56. Gastrostomy tube insertion outcomes in South Australian head and neck cancer patients. Australian Journal of Otolaryngology 2018, 1:21
  57. Myringoplasty outcomes of Indigenous Australians in the West Kimberley region of Western Australia. Australian Journal of Otolaryngology 2018; 1:18.
  58. Redefining indications for panendoscopy in the work up of head and neck squamous cell carcinoma. Journal of Laryngology and Otology 2018 Oct; 132(10): 901-905
  59. Endoscopic smartphone adaptors in Otolaryngology: How do they compare? Clinical Otolaryngology July 43(6): 1599-1602, 2018
  60. A systematic review of validated sinus surgery simulators, Clinical Otolaryngology 43(3): 812-822,  June 2018
  61. Pathophysiology of swallowing following oropharyngeal surgery for obstructive sleep apnoea syndrome. Neurogastroenterology & Motility 2018 30(5): e13277
  62. Penetrating neck injuries: An up to date guide to evaluation and management, 100(1): 6-11, 2018 Annals of the Royal College of Surgeons (England) Journal & Bulletin Journal.
  63. Benjamin Stew and Eng Ooi (2017). The Role of Simulation in Endoscopic Sinus Surgery Training, Paranasal Sinuses, InTech, Available from:
  64. Cost analysis of injection laryngoplasty under local anaesthesia versus general anaesthesia: An Australian perspective. Journal of Laryngology and Otology, 132 (2): 168-72, 2018
  65. Systematic review of patient reported outcomes following revision endoscopic sinus surgery. Am J Rhinol Allergy 31(4): 248-255, 2017
  66. Validity of the American College of Surgeons National Surgical Quality Improvement Program risk calculator in South Australian glossectomy patientsJournal of Laryngology and Otology 2018
  67. Survival outcomes following salvage surgery for oropharyngeal squamous cell carcinoma: A systematic review. Journal of Laryngology and Otology, 132(4): 299-313, 2017
  68. Scoping review of pediatric tonsillectomy quality of life instruments. 127(10): 2399-2406, Laryngoscope, 2017
  69. Paediatric tonsillectomy quality of life assessment instruments: A scoping review protocol. JBI Database of Systematic Reviews and Implementation Reports, 2017.
  70. Hyaluronic acid for post sinus surgery care: A systematic review and meta-analysis Journal of Laryngology and Otology, 131 (S1): S2-S11, 2017.
  71. A comparative study of voice outcomes and complication rates in patients undergoing injection laryngoplasty (IL) under local versus general anaesthesia: An Adelaide Voice Specialists experience. Journal of Laryngology and Otology, 131 (S1): S41-S46.
  72. Swallowing outcomes following primary surgical resection and primary free flap reconstruction for oral and oropharynx squamous cell carcinoma: A systematic review Laryngoscope, 126 (7): 1572-80, 2016
  73. The effect of nasal irrigation formulation on the antimicrobial activity of nasal secretions. International Forum of Allergy and Rhinology, 5(12): 1104-1100, 2015
  74. Swallowing outcomes following primary surgical resection and primary free flap reconstruction for oral and oropharyngeal squamous cell carcinomas: a systematic review protocol, JBI Database of Systematic Reviews and Implementation Reports [2015, 13(8):120-134
  75. Comparing surgical experience with performance on a sinus surgery simulator.  ANZ J of Surgery, 86(12): 990-995, 2015.
  76. Surgical management of airway stenosis by radiofrequency coblation.  Journal of Laryngology and Otology 129 Suppl 1: S21-6, 2015.
  77. Validation of virtual reality based simulations for endoscopic sinus surgery. Clinical Otolaryngology 40(6): 569-579,  2015.
  78. A randomized control trial of a middle meatal silastic stent in reducing adhesions in endoscopic sinus surgery.  International Forum of Allergy & Rhinology 5(6): 524-532, 2015.
  79. Coping with catastrophe: How vascular injury training improves patient outcomes. International Forum of Allergy & Rhinology 5(3): 247-252, 2015.
  80. Aquaporin expression profiles in normal sinonasal mucosa and chronic rhinosinusitis. International Forum of Allergy & Rhinology 4(11): 901-8, 2014.
  81. Fungicidal activity of lysozyme is inhibited in vitro by commercial sinus irrigation solutions. American Journal of Allergy and Rhinology 26(4): 298-301, 2012.
  82. Tumour-specific strategies: Chordoma published in the book, Interdisciplinary Endonasal Endoscopic Surgery of Skull Base Tumours (Thieme TN154761) editors Wolfgang Draf, Ulrike Bockmuhl, Ricardo L Carrau, Amin Kassam, and Peter Vajkoczy
  83. Endoscopic surgery of skull base chordomas.  J Neurosurg 73(6): 379-386, 2012.
  84. Lysozyme expression is increased in the sinus mucosa of patients with chronic rhinosinusitis. Rhinology 50(2): 147-56, 2012.
  85. The effect of Low-Fidelity Endoscopic Sinus Surgery Simulators on Surgical Skill. International Forum of Allergy & Rhinology 2012, 2(1): 20-6.
  86. Absence of Helicobacter pylori in pediatric adenoid hyperplasia. Archives of Otolaryngology Head and Neck Surgery 137(10): 998-1004, 2011.
  87. Human lysozyme has fungicidal activity against nasal fungi, American Journal of Allergy and Rhinology 25(4): 236-240, 2011.
  88. An alternative management approach to paranasal sinus fibro-osseous lesions. Int Forum Allergy Rhinol 2011, Jan 1 (1): 55-63.
  89. Intralesional corticosteroid injection and dilatation provides effective management of subglottic stenosis in Wegener’s granulomatosis. Laryngoscope 120(12): 2452-5, 2010.
  90. Adenoid cystic carcinoma of the pterygopalatine fossa presenting as facial pain. Journal of Otolaryngology Head and Neck Surgery 39(5): E37-8, 2010.
  91. Rhinologic surgical training. Otolaryngology Clinics of North America 43(3): 673-89, 2010.
  92. Innate immunity. Otolaryngology Clinics of North America 43(3): 473-87, 2010.
  93. E.H. Ooi, I.J. Witterick. How to interpret CT sinus scans for primary care physicians. Allergy & Asthma: A Canadian review for primary care physicians 2010
  94. Immunomodulatory effect of cytosine-phosphate-guanosine (CpG)-oligonucleotides in nonasthmatic chronic rhinosinusitis: an explant model. Am J Rhinol Allergy 2009 23(2): 123-9.
  95. Canine fossa trephine for the severely diseased maxillary sinus. American Journal of Allergy and Rhinology 2009 23(6): 615-8.
  96. Innate immunity in the paranasal sinuses: A review of nasal host defences. Am J Rhinol 22:13-19, 2007.
  97. Nasal mucosa expression of lactoferrin in patients with chronic rhinosinusitis. Laryngoscope 2007, 117(11): 2030-5, 2007.
  98. Human cathelicidin antimicrobial peptide is upregulated in the eosinophilic mucus subgroup of chronic rhinosinusitis patients. American Journal of Rhinology 200721(4): 395-401.
  99. Fungal allergens induce cathelicidin LL-37 expression in chronic rhinosinusitis patients in a nasal explant model. American Journal of Rhinology 200721(3): 367-372.
  100. Responses of peripheral blood lymphocytes in fungal extracts and staphylococcal superantigen B in chronic rhinosinusitis Laryngoscope 2007117(3): 411-4.
  101. Surfactant protein D expression in chronic rhinosinusitis patients and immune responses in vitro to Aspergillus and Alternaria in a nasal explant model. Laryngoscope 2007; 117(1): 51-57.
  102. Th2 immunological inflammation in allergic fungal sinusitis, nonallergic eosinophilic fungal sinusitis, and chronic rhinosinusitis. Am J Rhinol 20: 145-149, 2006.
  103. Persistent buccopharyngeal membrane in an adult. International Journal of Oral and Maxillofacial surgery 2005June; 34(4): 446-448.
  104. Management of lateral sinus thrombosis: update and literature review. Journal of Laryngology and Otology 2003Dec; 117(12): 932-9.
  105. Endoscopic removal of sinonasal inverted papilloma including endoscopic medial maxillectomy. Laryngoscope 2003111: 867-873.
  106. Colon Ischaemia from a Stammers hernia: A long-term complication after Billroth II gastrectomy. Anz J Surg200272(8): 601-603.
  107. Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility. Am J Physiol 1998 Nov; 275(5 Pt 1): G1173-8.

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